There are mixed reports about whether your body can become immune to CBD, but it is pretty unlikely, although there is potential for slight tolerance to build up. This is why starting low and slowly working up (uptitration method) is so important as it finds the right levels of cannabinoids for your body. If you are taking high doses (40-50mg) and find it is not working as well as it used to, try taking a break for a week before starting again at a reduced dose.
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